BIMU 8

CAS No. 134296-40-5

BIMU 8 ( —— )

Catalog No. M27487 CAS No. 134296-40-5

BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 163 Get Quote
10MG 236 Get Quote
25MG 394 Get Quote
50MG 582 Get Quote
100MG 827 Get Quote
500MG 1674 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BIMU 8
  • Note
    Research use only, not for human use.
  • Brief Description
    BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.
  • Description
    BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.(In Vitro):BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials amplitude without changing the membrane potential of any neuron in myenteric neurons of guinea pig ileum.(In Vivo):BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. In mice, BIMU 8 (10 μg; i.c.v) which is largely ineffective by parenteral routes induces antinociception.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    134296-40-5
  • Formula Weight
    378.9
  • Molecular Formula
    C19H27ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N[C@H]1C[C@@H]2N(C)[C@H](C1)CC2)(=O)N3C=4C(N(C(C)C)C3=O)=CC=CC4.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jian-Fa Zong, et al. [Studies on Alkaloid Constituents of Fritillaria Yuminensis]. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):495-499.
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